Neuroimaging findings in Alexander's disease

J Child Neurol. 1990 Jul;5(3):253-8. doi: 10.1177/088307389000500321.


We present the findings from magnetic resonance imaging, computed tomographic scan, and single photon emission computed tomography of the brain in a 2-year-old girl with Alexander's disease. Computed tomographic scans showed prominent low-density white matter throughout the cerebral hemispheres. Magnetic resonance imaging showed increased T2 signal from the cerebral white matter but not the cerebellum or brain stem. Single photon emission computed tomography revealed diminished cerebral metabolism, particularly in the frontal regions, as compared with the cerebellum.

Publication types

  • Case Reports

MeSH terms

  • Astrocytes / pathology
  • Brain / pathology
  • Brain Diseases, Metabolic / diagnosis
  • Energy Metabolism / physiology
  • Female
  • Humans
  • Infant
  • Magnetic Resonance Imaging*
  • Neuromuscular Diseases / diagnosis*
  • Neuromuscular Diseases / pathology
  • Spasms, Infantile / diagnosis*
  • Spasms, Infantile / pathology
  • Tomography, Emission-Computed, Single-Photon*
  • Tomography, X-Ray Computed*