Calcium fructoborate helps control inflammation associated with diminished bone health

Biol Trace Elem Res. 2013 Dec;155(3):315-21. doi: 10.1007/s12011-013-9800-y. Epub 2013 Aug 28.


Inflammation has been identified as a possible contributory factor to disruption of the normal bone remodeling process, a process essential to healthy bone mineral density. Several large population-based clinical studies have specifically shown that levels of C-reactive protein, an immune recognition protein that is a sensitive marker of inflammation, are inversely and independently associated with total bone mineral density. The evidence suggests that control of C-reactive protein levels may contribute to bone health by protecting against inflammation's disruption of the equilibrium between bone resorption and bone deposition. Calcium fructoborate, a patented complex of calcium, fructose, and boron found naturally in fresh and dried fruits, vegetables and herbs, and wine, is a sugar-borate ester. A growing body of peer-reviewed, published clinical research indicates that the calcium fructoborate significantly reduces serum levels of the C-reactive protein in humans, suggesting that this unique plant-mineral complex may contribute to bone health by controlling the inflammation associated with loss of bone mineral density.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Inflammatory Agents / pharmacology*
  • Bone Diseases / complications*
  • Bone and Bones / drug effects*
  • Bone and Bones / metabolism
  • Borates / pharmacology*
  • C-Reactive Protein / analysis
  • Calcium, Dietary / pharmacology
  • Dietary Supplements*
  • Fructose / analogs & derivatives*
  • Fructose / pharmacology
  • Humans
  • Inflammation / etiology*


  • Anti-Inflammatory Agents
  • Borates
  • Calcium, Dietary
  • calcium fructoborate
  • Fructose
  • C-Reactive Protein