Chitin microneedles for an easy-to-use tuberculosis skin test

Adv Healthc Mater. 2014 Mar;3(3):349-53. doi: 10.1002/adhm.201300185. Epub 2013 Aug 26.

Abstract

An easy-to-use tuberculosis skin test is developed with chitin microneedles that deliver purified protein derivative at the correct skin depth and result in a positive test in BCG-immunized guinea pigs.

Keywords: Mantoux test; chitin; diagnostics; microneedles; tuberculosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chitin / chemistry*
  • Equipment Design
  • Guinea Pigs
  • Needles
  • Skin / metabolism
  • Transdermal Patch
  • Tuberculin / chemistry
  • Tuberculin / immunology
  • Tuberculin Test / instrumentation*
  • Tuberculin Test / methods*
  • Tuberculosis / diagnosis*

Substances

  • Tuberculin
  • Chitin