Antioxidant and anti-fatigue activities of flavonoids from Puerariae radix

Afr J Tradit Complement Altern Med. 2011 Dec 29;9(2):221-7. doi: 10.4314/ajtcam.v9i2.6. eCollection 2012.


This study evaluated the antioxidant and anti-fatigue activities of flavonoids from Puerariae radix (FPR). In vitro antioxidant activities of FPR were investigated through hydroxyl and superoxide radical scavenging activities. In vivo anti-fatigue activity of FPR was investigated through loaded swimming exercise of mice. Results showed that FPR had not only in vitro antioxidant activities, but also an in vivo anti-fatigue activity in mice. FPR possessed superoxide and hydroxyl radical scavenging activity in in vitro experimental studies. In vivo experimental studies, FPR could evidently extend exhaustive swimming time of mice, inhibit the increase of blood lactic acid (BLA), decrease serum urea nitrogen (BUN) and malondialdehyde (MDA) contents, promote increases in the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX) of mice after swimming. The results provided an important basis for developing the FPR as a novel antioxidant and anti-fatigue compound.

Keywords: Puerariae radix; anti-fatigue; antioxidant; flavonoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Blood Urea Nitrogen
  • Drugs, Chinese Herbal / pharmacology
  • Drugs, Chinese Herbal / therapeutic use*
  • Fatigue / blood
  • Fatigue / drug therapy*
  • Fatigue / metabolism
  • Flavonoids / pharmacology
  • Flavonoids / therapeutic use*
  • Glutathione Peroxidase / metabolism
  • Hydroxyl Radical / metabolism
  • Lactic Acid / blood
  • Male
  • Malondialdehyde / blood
  • Mice
  • Mice, Inbred ICR
  • Physical Endurance / drug effects*
  • Phytotherapy*
  • Plant Roots
  • Pueraria / chemistry*
  • Superoxide Dismutase / metabolism
  • Superoxides / metabolism
  • Swimming


  • Antioxidants
  • Drugs, Chinese Herbal
  • Flavonoids
  • Superoxides
  • Hydroxyl Radical
  • Lactic Acid
  • Malondialdehyde
  • Glutathione Peroxidase
  • Superoxide Dismutase