Antibodies expose multiple weaknesses in the glycan shield of HIV

Nat Struct Mol Biol. 2013 Jul;20(7):771-2. doi: 10.1038/nsmb.2627.

Abstract

A shield of glycans coats the viral-envelope proteins of HIV. Recent work shows how broadly neutralizing antibodies can recognize this shield despite structural variation in these ‘self’ carbohydrate structures.

Publication types

  • News
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Antibodies, Neutralizing / immunology*
  • HIV Antibodies / immunology*
  • HIV Envelope Protein gp120 / immunology*
  • Humans
  • Peptide Fragments / immunology*
  • Polysaccharides / immunology*

Substances

  • Antibodies, Neutralizing
  • HIV Antibodies
  • HIV Envelope Protein gp120
  • HIV envelope protein gp120 (135-148)
  • Peptide Fragments
  • Polysaccharides
  • gp120 protein, Human immunodeficiency virus 1