The social capital surrounding health including health and well-being, the way in which they function as multi-dimensional constructs, and the potential stability of relationships among the social capital were examined across universities in Hawaii and Japan. Maintaining or strengthening social factors of collective and individual health and well-being is a core factor of social capital and is instrumental in reducing worry and increasing trust. Qualitative in-depth interviews with 64 male and female college students (32 college students at the University of Hawaii at Manoa; 32 college students at Reitaku University in Japan) were used to collect information on social capital of health and well-being and associated concepts; students' perceptions were grouped under 11 themes. The data indicates that social capital has an impact on college students' health and well-being. They also suggest that differences in health status and well-being can be plausibly attributed to processes associated with socio-environmental circumstances and situations.