Preparation and characterization of inclusion complexes of naringenin with β-cyclodextrin or its derivative

Li-Juan Yang; Shui-Xian Ma; Shu-Ya Zhou; Wen Chen; Ming-Wei Yuan; Yan-Qing Yin; Xiao-Dong Yang

doi:10.1016/j.carbpol.2013.07.010

Preparation and characterization of inclusion complexes of naringenin with β-cyclodextrin or its derivative

Carbohydr Polym. 2013 Oct 15;98(1):861-9. doi: 10.1016/j.carbpol.2013.07.010. Epub 2013 Jul 12.

Authors

Li-Juan Yang¹, Shui-Xian Ma, Shu-Ya Zhou, Wen Chen, Ming-Wei Yuan, Yan-Qing Yin, Xiao-Dong Yang

Affiliation

¹ Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650500, PR China. ljyyang@gmail.com

PMID: 23987422
DOI: 10.1016/j.carbpol.2013.07.010

Abstract

The inclusion complexation behavior, characterization and binding ability of naringenin with β-cyclodextrin and its derivatives were investigated in both solution and the solid state by means of XRD, DSC, SEM, (1)H and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of naringenin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high thermal stability of the naringenin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products.

Keywords: Characterization; Cyclodextrin; Inclusion complex; Inclusion mode; Naringenin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Availability
Flavanones / chemistry*
Flavanones / pharmacokinetics
Solubility
Water / chemistry*
beta-Cyclodextrins / chemistry*

Substances

Flavanones
beta-Cyclodextrins
Water
heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin
heptakis(2,6-O-dimethyl)beta-cyclodextrin
naringenin