Microbleeds in ischemic stroke are associated with lower serum adiponectin and higher soluble E-selectin levels

J Neurol Sci. 2013 Nov 15;334(1-2):83-7. doi: 10.1016/j.jns.2013.07.2513. Epub 2013 Aug 2.


Background: Cerebral microbleeds (CMBs) are the important indicators of cerebral small vessel disease. However, it is still unclear whether endothelial dysfunction is involved in CMBs. In this study, we performed a prospective study to investigate the correlation between sE-selectin (soluble E-selectin) or adiponectin and the prevalence of CMBs.

Methods: We recruited 133 consecutive patients with first-ever ischemic stroke for this study. Finally, 126 patients were analyzed. The number and presence of CMBs were detected and evaluated on susceptibility-weighted magnetic resonance imaging within two weeks after symptom onset. We assessed the serum levels of adiponectin and sE-selectin for patients.

Results: CMBs were detected in 63 subjects (50%) within 126 patients and more prevalent in mixed brain regions (55.6%). In binary logistic regression analysis, each 1SD-increase in adiponectin level was significantly conversely associated with the prevalence of CMBs after adjusting for age, sex and cardiovascular risk factors (OR = 0.55; 95% CI: 0.36-0.84); but sE-selectin was significantly positively associated with the prevalence of CMBs (OR = 1.09; 95% CI: 1.02-1.15). Furthermore, partial correlation analyses showed that sE-selectin remained significantly associated with and correlated conversely to adiponectin (r = -0.452, p = 0.001).

Conclusions: Endothelial injury may play a role in the pathogenesis of CMBs, and serum levels of adiponectin and sE-selectin were closely related to CMBs. Adiponectin might be protective for the prevalence of CMBs.

Keywords: Adiponectin; Cerebral microbleeds; Endothelial dysfunction; Ischemic stroke; Marker; sE-selectin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood*
  • Aged
  • Biomarkers / blood
  • Cerebral Hemorrhage / blood
  • Cerebral Hemorrhage / complications
  • Cerebral Hemorrhage / epidemiology
  • Cerebral Hemorrhage / pathology*
  • China / epidemiology
  • E-Selectin / blood*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuroimaging
  • Prevalence
  • Prospective Studies
  • Stroke / blood
  • Stroke / pathology*


  • Adiponectin
  • Biomarkers
  • E-Selectin
  • SELE protein, human