The Anopheles innate immune system in the defense against malaria infection

J Innate Immun. 2014;6(2):169-81. doi: 10.1159/000353602. Epub 2013 Aug 28.


The multifaceted innate immune system of insects is capable of fighting infection by a variety of pathogens including those causing human malaria. Malaria transmission by the Anopheles mosquito depends on the Plasmodium parasite's successful completion of its lifecycle in the insect vector, a process that involves interactions with several tissues and cell types as well as with the mosquito's innate immune system. This review will discuss our current understanding of the Anopheles mosquito's innate immune responses against the malaria parasite Plasmodium and the influence of the insect's intestinal microbiota on parasite infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anopheles / immunology*
  • Anopheles / parasitology
  • Hemocytes / immunology
  • Host-Parasite Interactions / immunology
  • Humans
  • Immunity, Innate / immunology*
  • Insect Vectors / immunology*
  • Insect Vectors / parasitology
  • Malaria / immunology*
  • Malaria / parasitology
  • Plasmodium / immunology*
  • Plasmodium / physiology
  • Signal Transduction / immunology