Enzyme-controllable delivery of nitric oxide from a molecular hydrogel

Chem Commun (Camb). 2013 Oct 14;49(80):9173-5. doi: 10.1039/c3cc45666h. Epub 2013 Aug 29.

Abstract

A β-galactosidase-responsive molecular hydrogelator of a nitric oxide (NO) donor can release NO in a controllable manner to improve wound healing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry
  • Hydrogel, Polyethylene Glycol Dimethacrylate / metabolism*
  • Hydrogel, Polyethylene Glycol Dimethacrylate / pharmacology
  • Mice
  • Naphthalenes / chemistry
  • Nitric Oxide / chemistry
  • Nitric Oxide / metabolism*
  • Nitric Oxide Donors / chemistry
  • Peptides / chemistry
  • Wound Healing / drug effects
  • beta-Galactosidase / metabolism*

Substances

  • Naphthalenes
  • Nitric Oxide Donors
  • Peptides
  • naphthalene
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Nitric Oxide
  • beta-Galactosidase