Endobronchial ultrasound-guided transbronchial needle aspiration in the mediastinal staging of non-small cell lung cancer: a meta-analysis

Ann Thorac Surg. 2013 Oct;96(4):1502-1507. doi: 10.1016/j.athoracsur.2013.05.016. Epub 2013 Aug 28.


In this article, we assessed the pooled sensitivity and specificity of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in studies during the last 10 years that have solely used EBUS-TBNA as a minimally invasive technique, with or without computed tomography or positron-emission tomography screening. The meta-analysis included 1,066 patients from 9 studies who underwent EBUS-TBNA. The results show EBUS-TBNA is a potential technique for the investigation, diagnosis, and staging of non-small cell lung cancer among patients with suspected lung cancer. It has excellent sensitivity, specificity, accuracy, positive predictive value, and negative predictive value. EBUS-TBNA is well tolerated and does not lead to complications in patients.

Keywords: 10.

Publication types

  • Meta-Analysis

MeSH terms

  • Bronchoscopy
  • Carcinoma, Non-Small-Cell Lung / diagnostic imaging
  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration*
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / pathology*
  • Mediastinum
  • Neoplasm Staging / methods
  • Sensitivity and Specificity