The plasma levels of relaxin-2 and relaxin-3 in patients with diabetes

Clin Biochem. 2013 Nov;46(16-17):1713-6. doi: 10.1016/j.clinbiochem.2013.08.007. Epub 2013 Aug 28.


Objectives: Relaxin-2 has been found to alleviate fibrosis in experimental diabetic cardiomyopathy. In addition, the levels of serum relaxin-3 were increased and correlated with all the component traits of metabolic syndrome. We investigated the levels of plasma relaxin-2 or relaxin-3 and their relationship to component traits in patients with diabetes.

Design and methods: We studied 33 newly diagnosed type 2 diabetes patients and 38 age-matched healthy subjects. Blood samples were taken at study entry, and relaxin-3, relaxin-2, fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, serum insulin and hemoglobin A1c (HbA1c) levels were measured.

Results: Relaxin-2 levels were significantly lower in patients with diabetes than in controls: the median plasma relaxin-2 concentration was 34.68 pg/mL (range, <29.00-50.81 pg/mL) in patients with diabetes and 45.80 pg/mL (range, <37.42-54.46 pg/mL) in controls (p=0.0150). However, no differences in relaxin-3 levels were observed between the diabetes group and controls (p=0.6550). The plasma levels of relaxin-2 or relaxin-3 were not correlated with systolic blood pressure (BP), diastolic BP, total cholesterol, LDL-C, HDL-C, triglyceride, fasting blood glucose, fasting insulin and HbA1c in patients with diabetes. Additionally, there was no correlation between the plasma concentrations of relaxin-2 and relaxin-3 in patients with diabetes (rs=0.225; p=0.208).

Conclusions: We conclude that the plasma levels of relaxin-2 in diabetes patients were lower than in controls, however, there are no difference in plasma relaxin-3 concentrations between controls and patients with diabetes. Relaxin-2 or relaxin-3 levels are not related to component traits in patients with diabetes.

Keywords: BP; Diabetes; HDL-C; HOMA2; HbA(1c); LDL-C; Relaxin-2; Relaxin-3; blood pressure; hemoglobin A(1c); high-density lipoprotein cholesterol; homeostasis model assessment; low-density lipoprotein cholesterol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Diabetes Mellitus, Type 2 / blood*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Relaxin / analogs & derivatives*
  • Relaxin / blood
  • Statistics, Nonparametric


  • RLN2 protein, human
  • RLN3 protein, human
  • Relaxin