Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer

Behav Pharmacol. 2013 Oct;24(7):569-79. doi: 10.1097/FBP.0b013e32836546fc.


Bipolar disorder is a severe mood disorder with high morbidity and mortality. Despite adequate treatment, patients continue to have recurrent mood episodes, residual symptoms, and functional impairment. Some preclinical studies have shown that histone deacetylase inhibitors may act on depressive-like and manic-like behaviors. Therefore, the aim of the present study was to evaluate the effects of sodium butyrate (SB) on behavioral changes in animal models of depression and mania. The animals were submitted to protocols of chronic mild stress or maternal deprivation for induction of depressive-like behaviors and subjected to amphetamine, or ouabain administration for induction of manic-like behaviors. SB reversed the depressive-like and manic-like behaviors evaluated in the animal models. From these results we can suggest that SB may be a potential mood stabilizer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Affect / drug effects
  • Animals
  • Antimanic Agents / pharmacology*
  • Behavior, Animal / drug effects
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / physiopathology
  • Butyric Acid / pharmacology*
  • Disease Models, Animal
  • Male
  • Rats
  • Rats, Wistar


  • Antimanic Agents
  • Butyric Acid