[Identification and Evaluation of the Neuroleptic Activity of Phenotropil]

Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(7):42-6.
[Article in Russian]

Abstract

The neuroleptic (antipsychotic) activity of phenotropil was studied in an experimental animal model. Phenotropil had a marked neuroleptic activity in models of positive (apomorphine-induced verticalization test) and negative (5-HTP-induced hyperkinesis test) symptoms of psychoses as well as in the m-cholinergic pathway hyperactivation (arecoline-induced tremor test). The compound markedly antagonized haloperidol catalepsy. Used in a single dose or as a course treatment, phenotropil did not provoke aggression nor intensify it. In contrast to typical and atypical antipsychotics, phenotropil had no sedative action and other adverse effects. It exhibited a positive effect on exploratory behavior and motor activity, had anxiolytic and antidepressant action.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Antipsychotic Agents / pharmacokinetics
  • Antipsychotic Agents / therapeutic use
  • Disease Models, Animal
  • Male
  • Mice
  • Motor Activity / drug effects
  • Piracetam / analogs & derivatives*
  • Piracetam / pharmacokinetics
  • Piracetam / therapeutic use
  • Psychotic Disorders / drug therapy*
  • Psychotic Disorders / metabolism
  • Rats
  • Treatment Outcome

Substances

  • Antipsychotic Agents
  • 4-phenylpiracetam
  • Piracetam