Effects of olive leave extract on metabolic disorders and oxidative stress induced by 2.45 GHz WIFI signals

Environ Toxicol Pharmacol. 2013 Nov;36(3):826-34. doi: 10.1016/j.etap.2013.07.013. Epub 2013 Aug 3.


We investigated the effect of olive leaves extract administration on glucose metabolism and oxidative response in liver and kidneys of rats exposed to radio frequency (RF). The exposure of rats to RF (2.45 GHz, 1h/day during 21 consecutive days) induced a diabetes-like status. Moreover, RF decreased the activities of glutathione peroxidase (GPx, -33.33% and -49.40%) catalase (CAT, -43.39% and -39.62%) and the superoxide dismutase (SOD, -59.29% and -68.53%) and groups thiol amount (-62.68% and -34.85%), respectively in liver and kidneys. Indeed, exposure to RF increased the malondialdehyde (MDA, 29.69% and 51.35%) concentration respectively in liver and kidneys. Olive leaves extract administration (100 mg/kg, ip) in RF-exposed rats prevented glucose metabolism disruption and restored the activities of GPx, CAT and SOD and thiol group amount in liver and kidneys. Moreover, olive leave extract administration was able to bring down the elevated levels of MDA in liver but not in kidneys. Our investigations suggested that RF exposure induced a diabetes-like status through alteration of oxidative response. Olive leaves extract was able to correct glucose metabolism disorder by minimizing oxidative stress induced by RF in rat tissues.

Keywords: Metabolism; Olive leaves; Oxidative stress; Radio frequencies.

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Blood Glucose / radiation effects
  • Body Weight / drug effects
  • Body Weight / radiation effects
  • Glucose / metabolism
  • Glucose Tolerance Test
  • Hyperglycemia / blood
  • Hyperglycemia / drug therapy
  • Kidney / metabolism
  • Kidney / pathology
  • Kidney / radiation effects
  • Liver / metabolism
  • Liver / pathology
  • Liver / radiation effects
  • Male
  • Metabolic Diseases / drug therapy*
  • Metabolic Diseases / etiology
  • Olea / chemistry*
  • Oxidative Stress / drug effects*
  • Oxidative Stress / radiation effects*
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry
  • Radiation Injuries, Experimental / drug therapy*
  • Radiation Injuries, Experimental / metabolism*
  • Radiation Injuries, Experimental / pathology
  • Radio Waves*
  • Rats
  • Rats, Wistar
  • Wireless Technology*


  • Antioxidants
  • Blood Glucose
  • Plant Extracts
  • Glucose