Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain

Nat Neurosci. 2013 Oct;16(10):1370-2. doi: 10.1038/nn.3503. Epub 2013 Sep 1.


To examine the role of gray and white matter niches for oligodendrocyte differentiation, we used homo- and heterotopic transplantations into the adult mouse cerebral cortex. White matter-derived cells differentiated into mature oligodendrocytes in both niches with equal efficiency, whereas gray matter-derived cells did not. Thus, white matter promotes oligodendrocyte differentiation, and cells from this niche differentiate more easily, even in the less supportive gray matter environment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Brain / cytology*
  • Brain / physiology*
  • Cell Differentiation / physiology*
  • Cell Transplantation / methods
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neurogenesis / physiology
  • Oligodendroglia / cytology
  • Oligodendroglia / physiology*
  • Oligodendroglia / transplantation*