Personalized network-based treatments in oncology

X Robin; P Creixell; O Radetskaya; C C Santini; J Longden; R Linding

doi:10.1038/clpt.2013.171

Personalized network-based treatments in oncology

Clin Pharmacol Ther. 2013 Dec;94(6):646-50. doi: 10.1038/clpt.2013.171. Epub 2013 Aug 29.

Authors

X Robin¹, P Creixell, O Radetskaya, C C Santini, J Longden, R Linding

Affiliation

¹ Cellular Signal Integration Group (C-SIG), Center for Biological Sequence Analysis (CBS), Department of Systems Biology, Technical University of Denmark (DTU), Lyngby, Denmark.

PMID: 23995267
DOI: 10.1038/clpt.2013.171

Abstract

Network medicine aims at unraveling cell signaling networks to propose personalized treatments for patients suffering from complex diseases. In this short review, we show the relevance of network medicine to cancer treatment by outlining the potential convergence points of the most recent technological and scientific developments in both drug design and signaling network analysis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Combined Chemotherapy Protocols / pharmacology
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Biomarkers / metabolism
Drug Design*
Humans
Molecular Targeted Therapy*
Neoplasms / drug therapy*
Neoplasms / metabolism
Precision Medicine / methods*
Protein Interaction Maps
Protein Processing, Post-Translational
Signal Transduction
Systems Biology

Substances

Biomarkers