Arthroscopic autologous chondrocyte implantation in the ankle joint

Knee Surg Sports Traumatol Arthrosc. 2014 Jun;22(6):1311-9. doi: 10.1007/s00167-013-2640-7. Epub 2013 Sep 1.

Abstract

Purpose: Autologous chondrocyte implantation (ACI) is an established procedure in the ankle providing satisfactory results. The development of a completely arthroscopic ACI procedure in the ankle joint made the technique easier and reduced the morbidity. The purpose of this investigation was to report the clinical results of a series of patients who underwent arthroscopic ACI of the talus at a mean of 7 ± 1.2-year follow-up.

Methods: Forty-six patients (mean age 31.4 ± 7.6) affected by osteochondral lesions of the talar dome (OLT) received arthroscopic ACI between 2001 and 2006. Patients were clinically evaluated using AOFAS score pre-operatively and at 12, 36 months and at final follow-up of 87.2 ± 14.5 months.

Results: The mean pre-operative AOFAS score was 57.2 ± 14.3. At the 12-month follow-up, the mean AOFAS score was 86.8 ± 13.4 (p = 0.0005); at 36 months after surgery, the mean score was 89.5 ± 13.4 (p = 0.0005); whereas at final follow-up of 87.2 ± 14.5 months it was 92.0 ± 11.2 (p = 0.0005). There were three failures. Histological and immunohistochemical evaluations of specimens harvested from failed implants generally showed several aspects of a fibro-cartilaginous tissue associated with some aspects of cartilage tissue remodelling as indicated by the presence of type II collagen expression.

Conclusion: This study confirmed the ability of arthroscopic ACI to repair osteochondral lesions in the ankle joint with satisfactory clinical results after mid-term follow-up.

Level of evidence: IV, retrospective case series.

MeSH terms

  • Adult
  • Ankle Joint / surgery*
  • Arthroscopy
  • Bone Diseases / surgery*
  • Bone Transplantation
  • Cartilage Diseases / surgery*
  • Chondrocytes / transplantation*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Talus / surgery*
  • Transplantation, Autologous
  • Treatment Outcome
  • Young Adult