Abstract
A key discovery in gastrointestinal motility has been the central role played by interstitial cells of Cajal (ICC) in generating electrical slow waves that coordinate contractions. Multielectrode mapping and multiscale modeling are two emerging interdisciplinary strategies now showing translational promise to investigate ICC function, electrophysiology, and contractions in the human gut.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Computer Simulation
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Gastrointestinal Motility*
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Humans
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Interstitial Cells of Cajal / physiology*
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Intestines / cytology
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Intestines / physiology*
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Models, Biological*
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Myoelectric Complex, Migrating
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Stomach / cytology
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Stomach / physiology*
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Translational Research, Biomedical*