Regulation of luminal acidification by the V-ATPase

Physiology (Bethesda). 2013 Sep;28(5):318-29. doi: 10.1152/physiol.00007.2013.


Specialized cells in the body express high levels of V-ATPase in their plasma membrane and respond to hormonal and nonhormonal cues to regulate extracellular acidification. Mutations in or loss of some V-ATPase subunits cause several disorders, including renal distal tubular acidosis and male infertility. This review focuses on the regulation of V-ATPase-dependent luminal acidification in renal intercalated cells and epididymal clear cells, which are key players in these physiological processes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acidosis, Renal Tubular / enzymology
  • Acidosis, Renal Tubular / genetics
  • Animals
  • Cell Membrane / enzymology*
  • Epididymis / enzymology*
  • Genetic Predisposition to Disease
  • Homeostasis
  • Humans
  • Hydrogen-Ion Concentration
  • Infertility, Male / enzymology
  • Infertility, Male / genetics
  • Kidney / enzymology*
  • Male
  • Mutation
  • Phenotype
  • Vacuolar Proton-Translocating ATPases / chemistry
  • Vacuolar Proton-Translocating ATPases / genetics
  • Vacuolar Proton-Translocating ATPases / metabolism*


  • Vacuolar Proton-Translocating ATPases