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. 2014 Apr 1;209(7):1028-31.
doi: 10.1093/infdis/jit468. Epub 2013 Aug 30.

IFITM3 and Susceptibility to Respiratory Viral Infections in the Community

Free PMC article

IFITM3 and Susceptibility to Respiratory Viral Infections in the Community

Tara C Mills et al. J Infect Dis. .
Free PMC article


Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection.

Keywords: H1N1; IFITM3; Influenza; LRTI; Virus; association study; genetics; infectious disease.

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    1. Brass AL, Huang IC, Benita Y, et al. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009;139:1243–54. - PMC - PubMed
    1. Li K, Markosyan RM, Zheng Y-M, et al. IFITM proteins restrict viral membrane hemifusion. PLoS Pathog. 2013;9:e1003124. - PMC - PubMed
    1. Everitt AR, Clare S, Pertel T, et al. IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 2012;484:519–23. - PMC - PubMed
    1. The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012;491:56–65. - PMC - PubMed
    1. Hindorff LA, MacArthur J, Morales J, et al. A catalog of published genome-wide association studies. Accessed 25 January 2012.

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