[Intrinsic radiosensitivity: predictive assays that will change daily practice]

Cancer Radiother. 2013 Oct;17(5-6):337-43. doi: 10.1016/j.canrad.2013.07.137. Epub 2013 Aug 30.
[Article in French]


The impact of curative radiotherapy depends mainly on the total dose delivered homogenously in the targeted volume. Nevertheless, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many radiation treatments. In a same population treated in one center with the same technique, it appears that individual radiosensitivity clearly exists, namely in terms of late side effects that are in principle non-reversible. This review details the different radiobiological approaches that have been developed to better understand the mechanisms of radiation-induced late effects. We also present the possibilities of clinical use of predictive assays in the close future.

Keywords: Effets indésirables; Late effects; Predictive assays; Radiotherapy; Radiothérapie; Tests radiosensibilité.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Apoptosis
  • Cells, Cultured / radiation effects
  • Fibroblasts / radiation effects
  • Genotype
  • Humans
  • Lymphocytes / radiation effects
  • Proteomics
  • Radiation Injuries / genetics
  • Radiation Tolerance / genetics*
  • Radiation Tolerance / physiology*
  • Radiotherapy / adverse effects
  • Radiotherapy Dosage