Abstract
The ligand-activated transcription factor aryl hydrocarbon receptor controls the activity of several components of the immune system, many of which play an important role in neuroinflammation. This review discusses the role of AhR in T cells and dendritic cells, its relevance for the control of autoimmunity in the central nervous system, and its potential as a therapeutic target for immune-mediated disorders.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmunity*
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Central Nervous System / immunology*
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Central Nervous System / metabolism*
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Dendritic Cells / immunology
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Dendritic Cells / metabolism
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Encephalomyelitis, Autoimmune, Experimental / immunology
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Encephalomyelitis, Autoimmune, Experimental / metabolism
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Humans
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Ligands
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Receptors, Aryl Hydrocarbon / metabolism*
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T-Lymphocyte Subsets / immunology
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T-Lymphocyte Subsets / metabolism
Substances
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Ligands
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Receptors, Aryl Hydrocarbon