Differential expression and functions of microRNAs in liver transplantation and potential use as non-invasive biomarkers

Abstract

MicroRNAs (miRNAs) are important regulators in many biologic processes and have been implicated in the control of genes relevant to acute rejection and liver functions. Here we review the miRNAs specifically expressed in allografts during acute rejection and discuss potential roles for these miRNAs in liver dysfunction. We focus on miRNAs dysregulated both in the liver and in peripheral blood mononuclear cells and include a discussion of the potential for these miRNAs as non-invasive biomarkers to reflect liver status posttransplant.

Keywords: Acute rejection; Circulating miRNA; Liver dysfunction; Liver transplantation; MicroRNA; Noninvasive biomarker.