p11 and its role in depression and therapeutic responses to antidepressants

Nat Rev Neurosci. 2013 Oct;14(10):673-80. doi: 10.1038/nrn3564.


Studies of the multifunctional protein p11 (also known as S100A10) are shedding light on the molecular and cellular mechanisms underlying depression. Here, we review data implicating p11 in both the amplification of serotonergic signalling and the regulation of gene transcription. We summarize studies demonstrating that levels of p11 are regulated in depression and by antidepressant regimens and, conversely, that p11 regulates depression-like behaviours and/or responses to antidepressants. Current and future studies of p11 may provide a molecular and cellular framework for the development of novel antidepressant therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Annexin A2 / metabolism*
  • Antidepressive Agents / therapeutic use*
  • Brain / drug effects
  • Brain / metabolism
  • Depression / drug therapy*
  • Depression / metabolism*
  • Depression / pathology
  • Disease Models, Animal
  • Gene Expression Regulation / drug effects
  • Humans
  • S100 Proteins / metabolism*


  • Annexin A2
  • Antidepressive Agents
  • S100 Proteins
  • S100 calcium binding protein A10