A Human Clinical, Histological, Histomorphometrical, and Radiographical Study on Biphasic HA-Beta-TCP 30/70 in Maxillary Sinus Augmentation

Clin Implant Dent Relat Res. 2015 Jun;17(3):610-8. doi: 10.1111/cid.12145. Epub 2013 Sep 4.

Abstract

Background: By mixing hydroxyapatite (HA) and tricalcium phosphate (TCP), biphasic calcium phosphate ceramics can be obtained, and by varying their ratio it is possible to tailor the characteristics of the biomaterial.

Purpose: The aim of the present human study was to evaluate the histological and radiographical aspects of bone formation in maxillary sinus augmentation using a 30/70 HA-beta-TCP with a reticular structure.

Materials and methods: A total of 12 patients, undergoing two-stage sinus augmentation procedure using HA-beta-TCP at a ratio of 30/70, were included in the present study. After a 6-month healing period, during implant insertion, radiographical analysis was performed, and then the bone core biopsies were harvested and processed for histology.

Results: At radiographic evaluation, the bone gain was on average 6.85 ± 0.60 mm. HA-beta-TCP 30/70 appeared to be lined by newly formed bone, with no gaps at the interface. The histomorphometric analysis revealed 26 ± 2% of residual grafted biomaterial, 29 ± 3% of newly formed bone, and 45 ± 2% of marrow spaces.

Conclusions: The present results indicate histologically the high biocompatibility and osteoconductivity of HA-beta-TCP 30/70, and clinically its successful use for sinus augmentation procedures.

Keywords: biphasic calcium phosphate; bone regeneration; histology; hydroxyapatite; sinus augmentation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biocompatible Materials
  • Biopsy
  • Calcium Phosphates / therapeutic use*
  • Dental Implantation, Endosseous / methods*
  • Durapatite / therapeutic use*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteogenesis / physiology*
  • Sinus Floor Augmentation / methods*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Biocompatible Materials
  • Calcium Phosphates
  • beta-tricalcium phosphate
  • Durapatite