Mosquito repellents based on a natural chromene analogue with longer duration of action than N,N-diethyl-meta-toluamide (DEET)

J Agric Food Chem. 2013 Oct 2;61(39):9293-7. doi: 10.1021/jf402635z. Epub 2013 Sep 23.


Mosquito repellents play a major role in reducing bites and therefore mitigating transmission of mosquito-borne diseases. There is concern by some about the reported neurotoxic effects of the popular repellent DEET. Also, a product with longer effective activity after application is needed. This paper describes the synthesis and repellent activity of (2,2 dimethyl-2H-chromen-5-yl)methanol, a derivative of chromene amide that is a compound from the plant Amyris texana . This compound is more potent and provides longer duration of protection than DEET against Aedes aegypti (L.), the primary vector that transmits pathogens causing yellow and dengue fevers in humans.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aedes / drug effects*
  • Animals
  • Anopheles / drug effects
  • Behavior, Animal / drug effects
  • Benzopyrans / chemical synthesis
  • Benzopyrans / pharmacology*
  • DEET / pharmacology
  • Female
  • Humans
  • Insect Bites and Stings / prevention & control*
  • Insect Repellents / chemical synthesis
  • Insect Repellents / pharmacology*
  • Kinetics
  • Osmolar Concentration


  • 2,2 dimethyl-2H-chromen-5-yl)methanol
  • Benzopyrans
  • Insect Repellents
  • DEET