Apparent liver blood flow during pregnancy: a serial study using indocyanine green clearance

Br J Obstet Gynaecol. 1990 Aug;97(8):720-4. doi: 10.1111/j.1471-0528.1990.tb16246.x.


Serial measurements of apparent liver blood flow and cardiac output were performed in 12 women at 12-14, 24-26 and 36-38 weeks of pregnancy and then at 10-12 weeks after delivery. Apparent liver blood flow was calculated from indocyanine green clearance. Cardiac output was measured by Doppler and cross-sectional echocardiography at the aortic valve. Postnatal apparent liver blood flow was 1.81 l/min and no significant change was demonstrated during pregnancy. In contrast cardiac output decreased from 7.46 l/min at 36-38 weeks gestation to 4.90 l/min after delivery. Apparent liver blood flow accounted for 24% of cardiac output during pregnancy. This increased to 37% after delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cardiac Output
  • Female
  • Humans
  • Indocyanine Green*
  • Liver / physiology
  • Liver Circulation*
  • Metabolic Clearance Rate
  • Postpartum Period
  • Pregnancy / physiology*
  • Pregnancy Trimester, First
  • Pregnancy Trimester, Second
  • Pregnancy Trimester, Third


  • Indocyanine Green