Visual evoked potentials in neuromyelitis optica and its spectrum disorders

Mult Scler. 2014 Apr;20(5):617-20. doi: 10.1177/1352458513503053. Epub 2013 Sep 5.

Abstract

Optic neuritis (ON) is a key feature of neuromyelitis optica (NMO). Recently, NMO patients of predominantly Afro-Brazilian origin were evaluated by visual evoked potentials (VEPs) and showed marked amplitude reductions. Here, we analyzed VEPs in a predominantly Caucasian cohort, consisting of 43 patients with definite NMO, 18 with anti-aquaporin (AQP) 4 antibody-seropositive NMO spectrum disorders and 61 matched healthy controls. We found reduced amplitudes in only 12.3%, prolonged latencies in 41.9% and a lack of response in 14.0% of NMO eyes. Delayed P100 latencies in eyes without prior ON suggested this was a subclinical affection. The data indicate heterogenous patterns in NMO, warranting further investigation.

Keywords: Aquaporin-4 antibody; P100 latency; neuromyelitis optica; neuromyelitis optica spectrum disorders; optic neuritis; visual evoked potential.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aquaporin 4 / immunology
  • Autoantibodies / blood
  • Biomarkers / blood
  • European Continental Ancestry Group
  • Evoked Potentials, Visual*
  • Female
  • Germany
  • Humans
  • Male
  • Middle Aged
  • Neuromyelitis Optica / diagnosis
  • Neuromyelitis Optica / ethnology
  • Neuromyelitis Optica / immunology
  • Neuromyelitis Optica / physiopathology*
  • Reaction Time
  • Retrospective Studies
  • Time Factors
  • Young Adult

Substances

  • AQP4 protein, human
  • Aquaporin 4
  • Autoantibodies
  • Biomarkers