Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes

Diabetes. 2014 Feb;63(2):655-62. doi: 10.2337/db13-0620. Epub 2013 Sep 5.

Abstract

Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring type-specific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0-2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antibodies, Neutralizing
  • Antibodies, Viral / blood*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Coxsackievirus Infections / complications*
  • Diabetes Mellitus, Type 1 / etiology
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / virology*
  • Enterovirus B, Human / physiology*
  • Europe / epidemiology
  • Female
  • Genotype
  • HLA-DQ Antigens / genetics
  • Humans
  • Infant
  • Male
  • Risk Factors
  • Young Adult

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • HLA-DQ Antigens