Glucagon-like immunoreactivity in hypothalamic neurons of the rat

Cell Tissue Res. 1990 Aug;261(2):355-8. doi: 10.1007/BF00318677.


Antisera specific for three different regions of pancreatic proglucagon were used to examine the distribution of such immunoreactivity in rat hypothalamus. Neurons in the supraoptic and paraventricular nuclei were immunoreactive with an antiserum against glucagon, but not with antisera directed towards the aminoterminal region of proglucagon (glicentin) or the glucagon-like peptide I sequence in the carboxyl-terminal region of proglucagon. These findings confirm a previous report of glucagon-like immunoreactivity in the supraoptic and paraventricular nuclei, but indicate that, while this material is immunochemically related to glucagon, it is not derived from a proglucagon-like precursor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Glucagon / analysis*
  • Glucagon / immunology
  • Hypothalamus / analysis*
  • Immune Sera
  • Immunohistochemistry
  • Male
  • Neurons / analysis*
  • Paraventricular Hypothalamic Nucleus / analysis
  • Proglucagon
  • Protein Precursors / immunology
  • Rats
  • Rats, Inbred Strains
  • Supraoptic Nucleus / analysis


  • Immune Sera
  • Protein Precursors
  • Proglucagon
  • Glucagon