Carbamazepine-induced DRESS syndrome in a child: rapid response to pulsed corticosteroids

Dermatol Online J. 2013 May 15;19(5):18170.

Abstract

DRESS syndrome is an idiosyncratic reaction to drugs, which can occur in both adults and children. To date there is no agreed upon criteria for its diagnosis; there is even less consensus on its management. We report the case of a 14- year-old boy with carbamazepine induced DRESS syndrome, predominantly involving the liver. He responded rapidly to high dose pulsed intravenous corticosteroids.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / therapeutic use*
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Brain Injuries / complications
  • Carbamazepine / adverse effects*
  • Carbamazepine / therapeutic use
  • Drug Hypersensitivity Syndrome / drug therapy
  • Drug Hypersensitivity Syndrome / etiology*
  • Drug Hypersensitivity Syndrome / pathology
  • Drug Therapy, Combination
  • Emollients / therapeutic use*
  • Fluocinolone Acetonide / administration & dosage
  • Fluocinolone Acetonide / therapeutic use*
  • Hepatomegaly / chemically induced
  • Hepatomegaly / drug therapy
  • Humans
  • Male
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / therapeutic use*
  • Mineral Oil / therapeutic use*
  • Pulse Therapy, Drug
  • Seizures / drug therapy
  • Seizures / etiology
  • Skin / pathology
  • Ursodeoxycholic Acid / therapeutic use*

Substances

  • Anti-Inflammatory Agents
  • Anticonvulsants
  • Emollients
  • Fluocinolone Acetonide
  • Carbamazepine
  • Ursodeoxycholic Acid
  • Mineral Oil
  • Methylprednisolone