IL-17 family: cytokines, receptors and signaling

Cytokine. 2013 Nov;64(2):477-85. doi: 10.1016/j.cyto.2013.07.022. Epub 2013 Sep 3.


The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. Although IL-17A is the signature cytokine produced by T helper 17 (Th17) cells, IL-17A and other IL-17 family cytokines have multiple sources ranging from immune cells to non-immune cells. The IL-17 family signals via their correspondent receptors and activates downstream pathways that include NFκB, MAPKs and C/EBPs to induce the expression of anti-microbial peptides, cytokines and chemokines. The proximal adaptor Act1 is a common mediator during the signaling of all IL-17 cytokines so far and is thus involved in IL-17 mediated host defense and IL-17-driven autoimmune conditions. This review will give an overview and recent updates on the IL-17 family, the activation and regulation of IL-17 signaling as well as diseases associated with this cytokine family.

Keywords: Act1; IL-17R; Interleukin 17; Signaling transduction.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammation / pathology
  • Interleukin-17 / metabolism*
  • Microbiota
  • Protein Binding
  • Receptors, Interleukin-17 / chemistry
  • Receptors, Interleukin-17 / metabolism*
  • Signal Transduction*


  • Interleukin-17
  • Receptors, Interleukin-17