Neurocognition in early-onset schizophrenia

Child Adolesc Psychiatr Clin N Am. 2013 Oct;22(4):715-26. doi: 10.1016/j.chc.2013.04.007. Epub 2013 Jun 18.


Cognitive impairment is recognized as a central feature of schizophrenia. Early-onset schizophrenia (EOS) represents a more severe variant of the disorder associated with onset in childhood or adolescence. Examination of the cognitive abnormalities of EOS offers the opportunity to explore how disease-related mechanisms may affect facets of cognitive development. This article summarizes and synthesizes available data with regards to the profile of cognitive impairments in EOS, their severity, and their evolution over the course of the disorder.

Keywords: Attention; Cognition; Development; Early onset; Executive function; Intelligence; Memory; Schizophrenia.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adolescent Development
  • Age of Onset
  • Attention / physiology
  • Child
  • Child Development
  • Cognition Disorders / complications
  • Cognition Disorders / physiopathology*
  • Disease Progression*
  • Executive Function / physiology
  • Humans
  • Intelligence / physiology
  • Memory, Short-Term / physiology
  • Neuropsychological Tests*
  • Prodromal Symptoms
  • Psychomotor Performance / physiology
  • Schizophrenia / complications
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*
  • Verbal Learning / physiology