Use of selenium-silymarin mix reduces lower urinary tract symptoms and prostate specific antigen in men

Phytomedicine. 2013 Dec 15;21(1):75-81. doi: 10.1016/j.phymed.2013.07.018. Epub 2013 Sep 5.


The aim of this double-blind, placebo controlled clinical trial was to assess the effects of a combination of selenium and silymarin in men with lower urinary tract symptoms, benign prostatic hyperplasia and a prostate specific antigen (PSA) ≤2.5ng/ml. The volunteers were randomized to two groups: the first one (n=26) received 240μg selenium (in the form of yeast l-selenomethionine) plus 570mg silymarin daily for 6 months and the second (n=29) received placebo. Outcome measures were changes in the International Prostate Symptom Score (IPSS), bladder volume (V), urinary flow rate, ultrasound estimated postvoid residual urine volume (RV), serum PSA, testosterone and selenium levels, safety clinical biochemistry, hematology and oxidative stress parameters at baseline and on day 180. The results showed statistically significant differences (p<0.05) between treatment and control groups for the following parameters: IPSS score, urodynamic parameters: maximal rate of urine flow (Qmax), average flow (Qave), V and RV, total PSA value and serum selenium levels. There was a significant reduction in PSA in the selenium-silymarin group but no effect on blood testosterone level. Overall the treatment was well-tolerated with no adverse effects.

Keywords: Selenium; Serum PSA; Silymarin; Urinary symptoms; Urodynamic parameters.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Double-Blind Method
  • Drug Combinations
  • Humans
  • Lower Urinary Tract Symptoms / blood
  • Lower Urinary Tract Symptoms / drug therapy*
  • Lower Urinary Tract Symptoms / etiology
  • Male
  • Middle Aged
  • Phytotherapy
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Prostate-Specific Antigen / blood*
  • Prostatic Hyperplasia / blood
  • Prostatic Hyperplasia / complications
  • Prostatic Hyperplasia / drug therapy*
  • Selenium / pharmacology
  • Selenium / therapeutic use*
  • Silybum marianum / chemistry*
  • Silymarin / pharmacology
  • Silymarin / therapeutic use*
  • Testosterone / blood
  • Trace Elements / pharmacology
  • Trace Elements / therapeutic use*
  • Urination / drug effects


  • Drug Combinations
  • Plant Extracts
  • Silymarin
  • Trace Elements
  • Testosterone
  • Prostate-Specific Antigen
  • Selenium