The alteration of spontaneous low frequency oscillations caused by acute electromagnetic fields exposure

Clin Neurophysiol. 2014 Feb;125(2):277-86. doi: 10.1016/j.clinph.2013.07.018. Epub 2013 Sep 4.


Objective: The motivation of this study is to evaluate the possible alteration of regional resting state brain activity induced by the acute radiofrequency electromagnetic field (RF-EMF) exposure (30min) of Long Term Evolution (LTE) signal.

Methods: We designed a controllable near-field LTE RF-EMF exposure environment. Eighteen subjects participated in a double-blind, crossover, randomized and counterbalanced experiment including two sessions (real and sham exposure). The radiation source was close to the right ear. Then the resting state fMRI signals of human brain were collected before and after the exposure in both sessions. We measured the amplitude of low frequency fluctuation (ALFF) and fractional ALFF (fALFF) to characterize the spontaneous brain activity.

Results: We found the decreased ALFF value around in left superior temporal gyrus, left middle temporal gyrus, right superior temporal gyrus, right medial frontal gyrus and right paracentral lobule after the real exposure. And the decreased fALFF value was also detected in right medial frontal gyrus and right paracentral lobule.

Conclusions: The study provided the evidences that 30min LTE RF-EMF exposure modulated the spontaneous low frequency fluctuations in some brain regions.

Significance: With resting state fMRI, we found the alteration of spontaneous low frequency fluctuations induced by the acute LTE RF-EMF exposure.

Keywords: ALFF; Amplitude of low frequency fluctuation; LTE; Long Term Evolution; MFG_R; MTG_L; PCL_R; RF-EMF; Radiofrequency electromagnetic fields; Resting state fMRI; STG_L; STG_R; amplitude of low frequency fluctuation; fALFF; fractional amplitude of low frequency fluctuation; left middle temporal gyrus; left superior temporal gyrus; radiofrequency electromagnetic fields; right medial frontal gyrus; right paracentral lobule; right superior temporal gyrus.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / physiology*
  • Brain Mapping
  • Cross-Over Studies
  • Double-Blind Method
  • Electromagnetic Fields*
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male