Sinister symbiosis: pathological hematopoietic-stromal interactions in CML

Ann Mullally; Benjamin L Ebert

doi:10.1016/j.stem.2013.08.009

Sinister symbiosis: pathological hematopoietic-stromal interactions in CML

Cell Stem Cell. 2013 Sep 5;13(3):257-8. doi: 10.1016/j.stem.2013.08.009.

Authors

Ann Mullally¹, Benjamin L Ebert

Affiliation

¹ Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

The impact of myeloid malignancies on the nonhematopoietic components of the bone marrow remains poorly understood. In this issue of Cell Stem Cell, Schepers et al. (2013) describe how malignant myeloid cells alter the endosteal hematopoietic stem cell (HSC) niche, resulting in the expansion of osteoblastic lineage cells that preferentially support malignant HSCs.

Publication types

Comment

MeSH terms

Animals
Bone Marrow / physiology*
Humans
Leukemia / physiopathology*
Mesenchymal Stem Cells / physiology*
Myeloproliferative Disorders / physiopathology*
Neoplastic Stem Cells / physiology*
Primary Myelofibrosis / physiopathology*
Stem Cell Niche*

Grant support

R01 HL082945/HL/NHLBI NIH HHS/United States