Targeting angiogenesis and the tumor microenvironment

Surg Oncol Clin N Am. 2013 Oct;22(4):629-39. doi: 10.1016/j.soc.2013.06.002. Epub 2013 Jul 26.


The role of the microenvironment during the initiation and progression of malignancy is appreciated to be of critical importance for improved molecular diagnostics and therapeutics. The tumor microenvironment is the product of a crosstalk between different cells types. Active contribution of tumor-associated stromal cells to cancer progression has been recognized. Stromal elements consist of the extracellular matrix, fibroblasts of various phenotypes, and a scaffold comprised of immune and inflammatory cells, blood and lymph vessels, and nerves. This review focuses on therapeutic targets in the microenvironment related to tumor endothelium, tumor associated fibroblasts, and the extracellular matrix.

Keywords: Angiogenesis; Growth factors; Integrins; Tumor associated fibroblast; Tumor microenvironment.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inducing Agents / therapeutic use*
  • Animals
  • Extracellular Matrix / drug effects
  • Fibroblasts / drug effects
  • Humans
  • Neoplasms / blood supply*
  • Neoplasms / drug therapy*
  • Neovascularization, Pathologic / drug therapy*
  • Tumor Microenvironment / drug effects*


  • Angiogenesis Inducing Agents