A second generation MRI contrast agent for imaging zinc ions in vivo

Medchemcomm. 2012 Apr 1;3(4):480-483. doi: 10.1039/C2MD00301E.


A Zn2+ specific GdDOTA derivative containing two bis-(3-pyrazolyl) units was prepared and characterized. Unlike a previously reported Zn2+ binding agent, the new agent binds to human albumin both in the presence and absence of Zn2+.