Profiling solute carrier transporters in the human blood-brain barrier

Clin Pharmacol Ther. 2013 Dec;94(6):636-9. doi: 10.1038/clpt.2013.175. Epub 2013 Sep 5.

Abstract

The neuroprotective function of the blood-brain barrier (BBB) presents a major challenge for drug delivery to the central nervous system (CNS). Critical to this function, BBB membrane transporters include the ATP-binding cassette (ABC) transporters, which limit drug penetration across the BBB, and the less-well-studied solute carrier (SLC) transporters. In this work, expression profiling of 359 SLC transporters, comparative expression analysis with kidney and liver, and immunoassays in brain microvessels (BMVs) identified previously unknown transporters at the human BBB.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood-Brain Barrier / metabolism*
  • Brain / blood supply*
  • Cerebral Cortex / metabolism
  • Gene Expression Profiling
  • Humans
  • Ion Pumps / metabolism
  • Kidney / metabolism
  • Liver / metabolism
  • Membrane Transport Proteins / metabolism*
  • Microvessels / metabolism*
  • Real-Time Polymerase Chain Reaction

Substances

  • Ion Pumps
  • Membrane Transport Proteins