Familial predisposition to renal disease in two generations of Pima Indians with type 2 (non-insulin-dependent) diabetes mellitus

Diabetologia. 1990 Jul;33(7):438-43. doi: 10.1007/BF00404096.


We studied the occurrence of renal disease by measuring serum creatinine and urine protein concentrations in the diabetic members of 316 Pima Indian families with Type 2 (non-insulin-dependent) diabetes in two successive generations to determine if diabetic renal disease aggregates in families. After adjustment for sex and other risk factors, proteinuria occurred among 14.3% of the diabetic offspring if neither parent had proteinuria, 22.9% if at least one diabetic parent had proteinuria, and 45.9% if both parents had diabetes and proteinuria. Among male offspring, an elevated serum creatinine concentration (greater than or equal to 177 mumol/l) was present in 11.7% if the parent had an elevated creatinine and in 1.5% if the parent did not. Thus, proteinuria and high serum creatinine aggregated in diabetic families, suggesting that susceptibility to renal disease is inherited independently of diabetes.

MeSH terms

  • Adult
  • Arizona
  • Blood Pressure
  • Creatinine / urine
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetic Nephropathies / epidemiology
  • Diabetic Nephropathies / genetics*
  • Diabetic Nephropathies / physiopathology
  • Family
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Indians, North American / genetics*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Prevalence
  • Proteinuria
  • Regression Analysis


  • Creatinine