Tapentadol hydrochloride: A novel analgesic

Saudi J Anaesth. 2013 Jul;7(3):322-6. doi: 10.4103/1658-354X.115319.


Tapentadol is a novel, centrally acting analgesic with dual mechanism of action, combining mu-opioid receptor agonism with noradrenaline reuptake inhibition in the same molecule. It has an improved side effect profile when compared to opioids and nonsteroidal anti-inflammatory drugs. The dual mechanism of action makes Tapentadol a useful analgesic to treat acute, chronic, and neuropathic pain.

Keywords: Nonsteroidal anti-inflammatory drugs; opioids; tapentadol hydrochloride.

Publication types

  • Review