The effect of testosterone levels on mood in men: a review

Psychosomatics. Nov-Dec 2013;54(6):509-14. doi: 10.1016/j.psym.2013.06.018. Epub 2013 Sep 7.


Background: The effects of both high and low levels of testosterone are wide ranging and can include changes in mood, often overlapping with symptoms of mood disorders.

Objective: We sought to review the literature on the correlation of high and low levels of testosterone on mood disorders in men.

Results: Based on limited studies, high levels of testosterone are related to increased rates of depression as well as hypomania, whereas low levels of testosterone are related to depressive disorders in certain subpopulations of patients. There is insufficient evidence to conclude that low testosterone level routinely leads to major depressive disorder in men.

Conclusions: Physicians should consider screening for low testosterone levels in certain subgroups of depressed men.

Publication types

  • Review

MeSH terms

  • Affect
  • Bipolar Disorder / metabolism*
  • Depressive Disorder / metabolism*
  • Humans
  • Male
  • Mood Disorders / metabolism
  • Testosterone / metabolism*


  • Testosterone