The ins and outs of hepatitis C virus entry and assembly

Nat Rev Microbiol. 2013 Oct;11(10):688-700. doi: 10.1038/nrmicro3098. Epub 2013 Sep 10.


Hepatitis C virus, a major human pathogen, produces infectious virus particles with several unique features, such as an ability to interact with serum lipoproteins, a dizzyingly complicated process of virus entry, and a pathway of virus assembly and release that is closely linked to lipoprotein secretion. Here, we review these unique features, with an emphasis on recent discoveries concerning virus particle structure, virus entry and virus particle assembly and release.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endosomes / virology
  • Hepacivirus / genetics
  • Hepacivirus / pathogenicity*
  • Hepacivirus / physiology
  • Hepatitis C / virology
  • Humans
  • Mice
  • Models, Biological
  • Receptors, Virus / metabolism
  • Tetraspanin 28 / metabolism
  • Viral Envelope Proteins / genetics
  • Viral Envelope Proteins / metabolism
  • Virus Assembly*
  • Virus Internalization*
  • Virus Release


  • Cd81 protein, mouse
  • Receptors, Virus
  • Tetraspanin 28
  • Viral Envelope Proteins
  • glycoprotein E2, Hepatitis C virus