Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Sep;58(3):560-5.

Major Histocompatibility Complex Class II Antigen Expression in Nerves in Leprosy; An Immunoelectronmicroscopical Study

Affiliations
  • PMID: 2401839

Major Histocompatibility Complex Class II Antigen Expression in Nerves in Leprosy; An Immunoelectronmicroscopical Study

S A Cowley et al. Int J Lepr Other Mycobact Dis. .

Abstract

A technique for immunoelectronmicroscopy has been used to investigate major histocompatibility class II expression in leprosy nerves. In normal nerves, endothelial cells and occasional endoneural cells (not Schwann cells) were constitutively class II positive. In both paucibacillary and multibacillary leprosy nerve biopsies, infiltrating leukocytes were positive but class II-positive Schwann cells were not seen. These observations indicate that Schwann cells may not be involved in presenting Mycobacterium leprae antigens to T cells in leprosy. This conflicts with evidence from in vitro studies, but may be explained by the fact that in vivo Schwann cells are surrounded by basement membranes and are closely associated with axons.

Similar articles

See all similar articles

Publication types

Substances

LinkOut - more resources

Feedback