Extracellular vesicle-mediated transfer of membranous components from the highly malignant T24 urinary carcinoma cell line to the non-malignant RT4 urinary papilloma cell line

Protoplasma. 2014 May;251(3):699-702. doi: 10.1007/s00709-013-0544-5. Epub 2013 Sep 10.


This communication reports the first experimental evidence that in the bladder cancer model, membranous components labelled with the DiO dye and the cholera toxin subunit B can be transported from highly malignant (T24) to non-malignant (RT4) cells by extracellular vesicles. Taking into account the presence of stable membranous nanostructures found by scanning electron microscopy, we suggest a possible uptake mechanism in recipient cells through fusion with highly curved membranous regions.

MeSH terms

  • Cell Line, Tumor
  • Exosomes / metabolism*
  • Humans
  • Microscopy, Electron, Scanning
  • Papilloma / metabolism*
  • Papilloma / ultrastructure
  • Urinary Bladder Neoplasms / metabolism*
  • Urinary Bladder Neoplasms / ultrastructure