Uncovering the mysteries of hantavirus infections

Nat Rev Microbiol. 2013 Aug;11(8):539-50. doi: 10.1038/nrmicro3066.

Abstract

Hantaviruses are negative-sense single-stranded RNA viruses that infect many species of rodents, shrews, moles and bats. Infection in these reservoir hosts is almost asymptomatic, but some rodent-borne hantaviruses also infect humans, causing either haemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). In this Review, we discuss the basic molecular properties and cell biology of hantaviruses and offer an overview of virus-induced pathology, in particular vascular leakage and immunopathology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / pathology
  • CD8-Positive T-Lymphocytes / virology
  • Capillary Permeability*
  • Carrier State / virology
  • Endothelial Cells / pathology
  • Endothelial Cells / virology
  • Genome, Viral*
  • Hantavirus / genetics
  • Hantavirus / immunology
  • Hantavirus / pathogenicity*
  • Hantavirus / physiology
  • Hantavirus Infections / immunology
  • Hantavirus Infections / pathology
  • Hantavirus Infections / virology*
  • Humans
  • Receptors, Virus / immunology
  • Rodentia / virology
  • Transcription, Genetic
  • Virus Internalization
  • Virus Replication

Substances

  • Receptors, Virus