Elucidating the immunological function of the Cryptococcus neoformans capsule

Future Microbiol. 2013 Sep;8(9):1107-16. doi: 10.2217/fmb.13.84.


The encapsulated fungal pathogen Cryptococcus neoformans represents a significant agent of life-threatening infections in immunocompromised subjects. A unique characteristic of Cryptococcus species is the presence of a polysaccharide capsule, which is essential for virulence and endows Cryptococcus with potent immunoregulatory properties. This review provides an overview of the immunological properties of the principal components of C. neoformans capsule.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cryptococcus neoformans / immunology*
  • Humans
  • Immunologic Factors
  • Polysaccharides / immunology*
  • Virulence Factors / immunology


  • Immunologic Factors
  • Polysaccharides
  • Virulence Factors