Increased levels of IL-17A in patients with fibromyalgia

Clin Exp Rheumatol. 2013 Nov-Dec;31(6 Suppl 79):S60-3. Epub 2013 Sep 10.

Abstract

Objectives: The aim of this study was to evaluate the plasma levels of IL-17A in fibromyalgia patients, and to look for any correlations between this data and the concentrations of some pro- and anti-inflammatory cytokines.

Methods: We performed a study including 58 fibromyalgia patients and 39 healthy women matched for age and body mass index. The plasma levels of IL-17A and other pro- and anti-inflammatory cytokines were measured by using the technique of cytometric bead array (CBA). The analysis of differences between groups was performed using Mann-Whitney test and the analysis of the correlations by Spearman's correlation test.

Results: The analyses showed that fibromyalgia patients present increased levels of IL-17A. They also revealed that plasma concentrations of IL17A positively correlate with levels of IL-2, IL-4 and IL-10, TNF and IFNγ.

Conclusions: As far as we are aware, this is the first study to demonstrate increased levels of IL17A in fibromyalgia patients. The positive correlation between the levels of IL-17A and of other cytokines strengthens the hypothesis of the involvement of inflammatory mechanisms in the development of this syndrome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Case-Control Studies
  • Female
  • Fibromyalgia / blood
  • Fibromyalgia / diagnosis
  • Fibromyalgia / immunology*
  • Humans
  • Inflammation Mediators / blood*
  • Interferon-gamma / blood
  • Interleukin-10 / blood
  • Interleukin-17 / blood*
  • Interleukin-2 / blood
  • Interleukin-4 / blood
  • Tumor Necrosis Factor-alpha
  • Up-Regulation

Substances

  • Biomarkers
  • IFNG protein, human
  • IL10 protein, human
  • IL17A protein, human
  • IL2 protein, human
  • IL4 protein, human
  • Inflammation Mediators
  • Interleukin-17
  • Interleukin-2
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • Interleukin-4
  • Interferon-gamma