Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer

Br J Cancer. 2013 Oct 1;109(7):1908-13. doi: 10.1038/bjc.2013.540. Epub 2013 Sep 10.


Background: Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously.

Methods: Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases.

Results: Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ≤1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50-1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m(-2) (RR=0.56; 95% CI: 0.36-0.89).

Conclusion: Coffee may protect against Type I EC in obese postmenopausal women.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Body Mass Index
  • Caffeine*
  • Coffee*
  • Eating
  • Endometrial Neoplasms / epidemiology*
  • Female
  • Food Preferences
  • Humans
  • Middle Aged
  • Obesity
  • Postmenopause
  • Prospective Studies
  • Risk Factors
  • Surveys and Questionnaires
  • Xanthines / administration & dosage*


  • Coffee
  • Xanthines
  • methylxanthine
  • Caffeine